https://www.johnson-flylab.com/terminal-patterning2 daily 0.75 2017-07-14 https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500011410439-X4ESRI1CGQR1BSW2LGMP/hkb+dorsal.jpg Terminal Patterning2 A wild type embryo (~2.5h old) showing successful patterning of the termini (red) and dorso-ventral axis (green). These patterning systems rely on restricted cell signalling events and serve as excellent paradigms in which to understand the mechanisms how cell signalling is controlled. https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500011176331-YETGITFN8TXLDC03VC94/image-asset.jpeg Terminal Patterning2 Maternal effect mutant phenotype classes. Actual images of cuticles laid by mutant mothers (left), illustrations of these (middle) and embryonic fate maps interpreted from this work. Acron (A) and Telson (Te) are the termini, Head (He), Thoracic (Th) and Abdomenal (A) regions are shown. https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500011707229-3HT7LJDBCRXE74C53S91/image-asset.png Terminal Patterning2 Activation of the Torso cell signalling pathway at each end of the embryo drives the patterning program in these regions. https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500011750503-9RBB598JG8T5M6QPLWNA/image-asset.jpeg Terminal Patterning2 Expression of the terminal class genes in the ovary (egg chamber). The nurse cells (Nc) load the oocyte (oo) with gene products for embryonic development. Note that tsl expression is limited to cells at each end of the oocyte. https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500013570748-6WRUBZ0582WT06GB92E5/image-asset.jpeg Terminal Patterning2 Embryo laid by female expressing tsl in all ovarian follicle cells causes loss of central segments and enlarged termini. https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500011629066-4CJ0E38N4BR4WE6AGI5O/terminal+phen.jpg Terminal Patterning2 Eggs laid by terminal class mutant mothers all fail to develop structures posterior to the A7 segment, and have a disrupted anterior. https://www.johnson-flylab.com/contact daily 0.75 2025-02-20 https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500620963402-SHHEXODO3P3XNAG0LKM4/Screen+Shot+2017-07-21+at+5.09.02+PM.png Contact https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499606860639-XXLPW1DYIPRHIP3FAKDP/SG.jpg Contact https://www.johnson-flylab.com/projects daily 0.75 2021-05-06 https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499601110160-5E0O1TNIUS1J0CJSBB3O/image-asset.png Projects https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499600859833-3BAGCBDFB26U3J0USA7B/PHM+G+ELAV+R+4X+merge.jpg Projects https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1500619459516-BDYACYZOCUYJ9COSV1Z5/image-asset.png Projects https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1553148336941-8NKQYFTCYFOYSFD2TEWP/Screen+Shot+2019-03-21+at+5.04.54+pm.png Projects https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499606910140-QHMQ64CKMMATAO4HDSIA/Screen+Shot+2017-07-06+at+9.51.40+PM.png Projects https://www.johnson-flylab.com/people daily 0.75 2022-08-02 https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1556970583405-14YBL8LGDVCZE1J7O19L/Sarah.JPG People https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1578886504668-VR0Q5IY2V8EL3M1HDSJP/IMG_9971.jpg People https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1578886158556-I8RBU5V3Q2TXWQ6FBK4D/IMG_9974.jpg People https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499605922747-N9JXVSW8CLGFJ2TB45CI/image-asset.jpeg People https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1659409949774-1OAVIIDX3XJ6BVWH153Q/Felipe.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.johnson-flylab.com/publications daily 0.75 2022-08-02 https://www.johnson-flylab.com/home daily 1.0 2025-02-20 https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499598427184-SIR6946EB4MER0JUOTM4/hkb+dorsal.jpg Drosophila Developmental Cell Signalling https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1499599464524-EF72K388XTK15754NFNF/pubs+image.jpg Drosophila Developmental Cell Signalling https://images.squarespace-cdn.com/content/v1/5949e58aa5790a3989faf3e6/1538027283160-3SCLH2XA3U1WAYPJ504N/homepage.jpg Drosophila Developmental Cell Signalling https://www.johnson-flylab.com/home-alt-bedford daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500612440-PGQSIY8KL9F7T5VIXQLO/chambers-2.jpg Home Alt A better world Starts with a choice Contact Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500503574-5BAPXZO9U06UV61P49UO/chambers1.jpg Home Alt Sustainability Starts with you Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500933384-LII4SRIPHFYOUFX0UCXC/chambers-4.jpg Home Alt A better world Starts with a choice Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390504287124-HQ8GNX1JCE22V047MSQ9/chambers-8.jpg Home Alt Preserve Nature Join Us